SYNGR4 AND PLEKHB1 DEREGULATION IN MOTOR NEURONS OF AMYOTROPHIC LATERAL SCLEROSIS MODELS: POTENTIAL CONTRIBUTIONS TO PATHOBIOLOGY

SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology

Amyotrophic lateral sclerosis is the most common adult-onset neurodegenerative disease affecting motor neurons.Its defining feature is progressive loss of motor neuron function in the cortex, brainstem, and spinal cord, leading to paralysis and death.Despite major advances in identifying genes that can cause disease when mutated and model the disea

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Stand-Alone Posterior Expandable Cage Technique for Adjacent Segment Degeneration with Lumbar Spinal Canal Stenosis: A Retrospective Case Series

Background and Objectives: Symptomatic adjacent segment degeneration (ASD) with lumbar spinal canal stenosis (LSCS) is a common complication after spinal intervention, particularly interbody fusion.Stand-alone posterior expandable cages enable interbody fusion with preservation of the previous operation site, and screw-related complications are avo

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Poly[bis(μ3-dodecyl sulfato)calcium]

In the title compound [Ca(C12H25O4S)2]n, the unique CaII ion lies on an inversion center and is coordinated Braces in a slightly distorted octahedral environment by six O atoms from dodecyl sulfate anions.The crystal structure is based on hydrocarbon (dodecyl sulfate) layers which sandwich the CaII ions.Within the layers, the hydrocarbon zigzag cha

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Doubt Undogmatized

It has become almost a conventional wisdom to argue that Cartesian scepticism poses a far more radical sceptical threat than its classical Pyrrhonian counterpart.Such a view fails to recognise, however, that there is a species of sceptical concern that can only Sailing Vests plausibly be regarded as captured by the Pyrrhonian strategy.For whereas C

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